FOLIO / PAPERS
A paper is not its conclusion.
Notes on what each paper asks, what the evidence supports, and what remains unshown.
Latest read.
Paper 060
SYS6010, Epidermal Growth Factor Receptor-Targeting Antibody-Drug Conjugate for Advanced Non-Small Cell Lung Cancer: A Phase 1 Trial
Read on
以 SYS6010 为例，拆解肿瘤药物一期论文如何报告患者流向、安全性、剂量选择、初步疗效、药代及探索性分析。
Cancer Cell2026
Rhythm.
Last year60 papers
JanFebMarAprMayJunJulAugSepOctNovDec
none1 paper2 papers3 papers4 papers5 papers
2026
Publication lag.
- This year
- 4270%
- 1–3 years old
- 1220%
- 4–5 years old
- 23%
- Over 5 years
- 47%
Sources.
Top journals5 of 33
BMC Medicine11
Cell4
European Journal of Epidemiology4
Nature3
Nature Genetics3
Discovered through4 routes
Keywords35
Journal news17
Social media6
Personal recommendation2
All papers
60 / 60
060SYS6010, Epidermal Growth Factor Receptor-Targeting Antibody-Drug Conjugate for Advanced Non-Small Cell Lung Cancer: A Phase 1 Trial以 SYS6010 为例，拆解肿瘤药物一期论文如何报告患者流向、安全性、剂量选择、初步疗效、药代及探索性分析。Cancer Cell · 2026 · read 2026-09-07article★★★☆☆059Association of the CHG Index with the Onset, Progression, and Prognosis of Cardiovascular-Kidney-Metabolic Syndrome: Findings from Two Large Prospective CohortsUK Biobank and hospital CAD cohort study linking the CHG index with incident metabolic renal and cardiovascular outcomes and subsequent MACCE riskDiabetology & Metabolic Syndrome · 2026 · read 2026-07-24article★★★☆☆058Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet and Cardiovascular Disease and ArrhythmiasUK Biobank cohort study comparing MIND MEDAS RFS and HDI diet scores for incident cardiovascular disease and cardiac arrhythmia riskBMC Medicine · 2025 · read 2026-07-16article★★★☆☆057Associations between Retinal Morphological Features and Risk of Depression and Anxiety DisordersUK Biobank OCT cohort study linking thinner GCIPL and macular thickness to higher incident depression risk while finding no stable association with anxiety disordersBMC Medicine · 2026 · read 2026-07-16article★★★☆☆056Social Isolation and 59 Common Health Conditions: Insights from Observational and Genetics AnalysesUK Biobank outcome-wide study linking social isolation mainly with mortality-related outcomes and finding little MR evidence for broad causal effectsBMC Medicine · 2026 · read 2026-07-15article★★★☆☆055Cardiorespiratory Fitness, Genetic Susceptibility, and the Risk of Chronic Obstructive Pulmonary Disease: Findings from Observational and Two-Sample Bidirectional Mendelian Randomisation AnalysesUK Biobank and Mendelian randomisation study linking higher cardiorespiratory fitness with lower incident COPD risk across genetic risk strataBMC Medicine · 2026 · read 2026-07-15article★★★★★054Adherence to the EAT-Lancet Diet, Plasma Proteomics, and Risk of Venous Thromboembolism: A Large-Scale Prospective Cohort StudyUK Biobank prospective cohort study linking EAT-Lancet diet adherence with lower incident VTE DVT and PE risk and exploratory plasma proteomic mediationBMC Medicine · 2026 · read 2026-07-15article★★☆☆☆053Sleep and Physical Activity Trade-Offs and Dementia Risk: A Prospective Cohort Study in UK Biobank ParticipantsUK Biobank accelerometer study using 24-hour compositional time-use substitutions to relate sleep physical activity and inactivity trade-offs to dementia riskBMC Medicine · 2025 · read 2026-07-15article★★☆☆☆052Joint Associations of Device-Measured Step Count and Sleep Duration with Incident Major Adverse Cardiovascular Events: Prospective Analysis of the UK BiobankUK Biobank accelerometer study linking device-measured step count and sleep duration with incident major adverse cardiovascular events riskeClinicalMedicine · 2026 · read 2026-07-15article★★★☆☆051Physical Activity Patterns and Cardiovascular Disease Risk in Adults with Overweight or Obesity: A Prospective Cohort StudyUK Biobank accelerometer study comparing concentrated and regularly distributed MVPA patterns with incident cardiovascular disease risk in adults with overweight or obesityBMC Medicine · 2026 · read 2026-07-13article★★★☆☆050Associations of Moderate-to-Vigorous Physical Activity Timing With Type 2 Diabetes Incidence in UK Biobank and Prevalent Glycemic Measures in NHANESUK Biobank and NHANES study linking afternoon-evening MVPA timing with lower incident type 2 diabetes risk and more favorable glycemic measuresDiabetes Care · 2026 · read 2026-07-13article★★★☆☆049Waist Circumference and Grip Strength and Their Joint Relations to Type 2 Diabetes Incidence in UK BiobankUK Biobank cohort study linking waist circumference grip strength and their joint phenotype to incident type 2 diabetes riskBMC Medicine · 2026 · read 2026-07-13article★★★☆☆048Association between Air Pollution Exposure and Increased Chronic Kidney Disease Risk: The Modifying Effects of Genetic Susceptibility, Transcriptomic, and Proteomic SignaturesUK Biobank environmental epidemiology article linking long-term air pollution exposure to incident chronic kidney disease risk with mediation genetic susceptibility and multiomics explorationBMC Medicine · 2026 · read 2026-07-09article★★★☆☆047Plant-Based Diets, Ultra-Processed Foods, and Risks of Mortality and Major Chronic Diseases: A Prospective Cohort StudyUK Biobank nutritional epidemiology article comparing healthful and unhealthful plant-based diet scores split by ultra-processed food content for mortality T2DM CVD and cancer riskThe Lancet Regional Health – Europe · 2026 · read 2026-07-09article★★★☆☆046Diet Quality and Progression from Health to Chronic Disease, Multimorbidity and Mortality in the UK BiobankUK Biobank nutritional epidemiology article using multi-state models to link diet quality scores with transitions from healthy status to chronic disease multimorbidity and mortalityBMC Medicine · 2026 · read 2026-07-09article★★★★☆045Possible Selection Bias in Mendelian Randomization Studies: Effect of Body Mass Index on Breast Cancer as an ExampleCritical note on GWAS survivor selection bias in MR using BMI and breast cancer as an exampleAmerican Journal of Epidemiology · 2026 · read 2026-07-08article★★☆☆☆044Social Isolation and Loneliness Associate with Early Menopause and Mortality in Women: A UK Biobank Cohort StudyUK Biobank study linking social isolation and loneliness with early menopause history and all-cause mortality riskBMC Medicine · 2026 · read 2026-07-08article★★★☆☆043Dose-Response Associations of Intermittent Lifestyle Physical Activity Micropatterns and Incident Type 2 DiabetesUK Biobank accelerometry study linking intermittent lifestyle physical activity micropatterns to incident type 2 diabetes riskDiabetes Care · 2026 · read 2026-07-08article★★★☆☆042Health Benefits of Leisure-Time Physical Activity by Socioeconomic Status, Lifestyle Risk, and Mental Health: A Multicohort StudyMulticohort study linking leisure-time physical activity to disease-free years across socioeconomic lifestyle and mental health subgroupsThe Lancet Public Health · 2025 · read 2026-07-07article★★★☆☆041Combined Effect of Biological Age and Fine Particulate Matter Pollution with Risk of Nonalcoholic Fatty Liver Disease in the UK Biobank: A Prospective Cohort StudyUK Biobank cohort study linking biological age and long-term PM2.5 exposure to incident NAFLD riskAmerican Journal of Epidemiology · 2026 · read 2026-07-07article★★★☆☆040Air Pollutants, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Large Prospective Cohort StudyUK Biobank cohort study linking long-term air pollution AMD PRS and additive interaction to incident age-related macular degeneration riskEuropean Journal of Epidemiology · 2026 · read 2026-07-06article★★★☆☆039Night Shift Work, Dietary Patterns, and Coronary Heart DiseaseUK Biobank cohort study examining night shift work dietary fiber meat avoidance and incident coronary heart disease riskEuropean Journal of Epidemiology · 2026 · read 2026-07-06article★★★☆☆038A Newly Developed Circadian Imbalance Index (CII) and Risk of Cardiovascular-Kidney-Metabolic Disease in the UK BiobankUK Biobank cohort study linking a newly constructed circadian imbalance index and night shift work to incident CKM disease riskEuropean Journal of Epidemiology · 2026 · read 2026-07-06article★★★☆☆037Adiposity and the Risk of Aortic Aneurysm: Results from the UK Biobank, Japan-Specific Health Check-ups Study and a Systematic Review and Meta-Analysis of Cohort StudiesReview with original cohort analyses and meta-analysis linking BMI and abdominal adiposity to aortic aneurysm riskEuropean Journal of Epidemiology · 2026 · read 2026-07-03review★★★☆☆036Glycemic Index Glycemic Load and Risk of Dementia: A Prospective Analysis within the UK Biobank CohortUK Biobank nutritional epidemiology article linking dietary glycemic index and load to incident dementia riskInternational Journal of Epidemiology · 2025 · read 2026-07-02article★★★☆☆035Role of Socioeconomic Status in Modifying the Relationship between Alcohol Use and Injury Events: Evidence from the UK BiobankUK Biobank social epidemiology article on alcohol use socioeconomic status and fatal or hospitalised injury riskJ Epidemiol Community Health · 2026 · read 2026-07-02article★★★☆☆034Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank CohortUK Biobank causal environmental epidemiology article estimating dementia risk reductions under hypothetical PM2.5 threshold interventionsEnvironmental Health Perspectives · 2025 · read 2026-07-01article★★★★☆033Non-Invasive Profiling of the Tumour Microenvironment with Spatial EcotypesPan-cancer spatial ecotype article introducing Spatial EcoTyper and Liquid EcoTyper to profile tumour microenvironment states from tissue transcriptomes and plasma cfDNA methylationNature · 2026 · read 2026-06-29article★★★★☆032Ecotypes of Triple-Negative Breast Cancer in Response to ChemotherapySingle-cell and spatial transcriptomic article linking TNBC archetypes metaprograms macrophage states and ecotypes to neoadjuvant chemotherapy responseNature · 2026 · read 2026-06-29article★★★★☆031Evaluating the Role of Pretraining Dataset Size and Diversity on Single-Cell Foundation Model PerformanceBenchmarking article showing current single-cell foundation models often saturate with small pretraining subsets and do not reliably benefit from naive data scaling or diversity increasesNature Methods · 2026 · read 2026-06-12article★★★☆☆030Challenges and Future Directions for Mendelian RandomizationPerspective on MR credibility assumptions evidence triangulation selection bias diverse samples and molecular phenotype challengesNature Genetics · 2026 · read 2026-06-12article★★★☆☆029Spatially Resolved Single-Cell Analyses of Human Meningioma Identify Novel Cell States Influencing Tumor Microenvironment and ProgressionSpatial single-cell and Visium HD article linking meningioma myeloid cell states tumor-dura reprogramming and progression risk beyond molecular groupNature Genetics · 2026 · read 2026-06-10article★★★★☆028Daraxonrasib in Previously Treated Advanced RAS-Mutated Pancreatic CancerPhase 1-2 article on oral RAS(ON) inhibition with daraxonrasib in previously treated RAS-mutated pancreatic cancerThe New England Journal of Medicine · 2026 · read 2026-06-08article★★★★☆027AutoScientists: Self-Organizing Agent Teams for Long-Running Scientific ExperimentationPreprint on a decentralized self-organizing multi-agent system for long-running scientific experiment search across biomedical ML GPT training optimization and protein fitness predictionarXiv · 2026 · read 2026-06-02article★★★☆☆026Genetic Analysis of Circulating Metabolic Traits in 619,372 IndividualsArticle on large-scale NMR metabolomics GWAS integrating low-frequency variants fine mapping colocalization and cis-MR for disease and drug target interpretationNature · 2026 · read 2026-05-27article★★★★☆025Epithelial-to-Mesenchymal Transition as a Central Driver of Tumor Cell PlasticityReview on EMT as a continuum of tumor cell plasticity states driving metastasis immune evasion therapy resistance and therapeutic vulnerabilitiesNature Cancer · 2026 · read 2026-05-27review★★★★★024A Multimodal Ocular Aging Index Reveals Proteomic Pathways and Predicts Incident Age-Related Eye DiseasesUK Biobank multi-omics study defining MOAI and linking ocular aging acceleration to incident AMD cataract and inflammation-related proteomic pathwaysnpj Aging · 2026 · read 2026-05-26article★★★☆☆023A Pan-Cancer Single-Cell Transcriptional Atlas of Tumor Infiltrating Myeloid CellsPan-cancer single-cell atlas of tumor-infiltrating myeloid cells covering mast cells dendritic cells TAM states and myeloid heterogeneityCell · 2021 · read 2026-05-20article★★★★★022Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck CancerSingle-cell RNA-seq article on HNSCC tumor ecosystems p-EMT leading-edge malignant programs CAFs and nodal metastasisCell · 2017 · read 2026-05-20article★★★★★021Dissecting the Multicellular Ecosystem of Metastatic Melanoma by Single-Cell RNA-seqClassic single-cell RNA-seq article on metastatic melanoma malignant-cell states TME composition targeted therapy resistance and T cell exhaustionScience · 2016 · read 2026-05-20article★★★★★020Single-Cell RNA-seq Highlights Intratumoral Heterogeneity in Primary GlioblastomaEarly single-cell RNA-seq article on malignant cell-state heterogeneity in primary glioblastomaScience · 2014 · read 2026-05-19article★★★★★019Advances and Applications in Single-Cell and Spatial GenomicsReview on single-cell and spatial genomics technologies multi-omics cell atlases computational challenges and clinical translationScience China Life Sciences · 2024 · read 2026-05-18review★★★★☆018Interpretation Extrapolation and Perturbation of Single CellsReview on single-cell perturbation modelling causal inference mechanistic discovery extrapolation and population tracingNature Reviews Genetics · 2026 · read 2026-05-18review★★★☆☆017Advancing AI for Multi-Omics and Clinical Data Integration in Basic and Translational Cancer ResearchReview on AI-driven multi-omics and clinical data integration in precision oncology covering foundation models multimodal fusion digital twins and XAINature Reviews Cancer · 2026 · read 2026-05-18review★★★★☆016Recommendations for Robust and Reproducible Research on FerroptosisExpert Recommendation on robust and reproducible ferroptosis research covering detection markers chemical tools animal models and experimental interpretationNature Reviews Molecular Cell Biology · 2025 · read 2026-05-15review★★★☆☆015Genetic Association and Machine Learning Improve the Prediction of Type 1 Diabetes RiskArticle on machine learning genetic risk prediction for type 1 diabetes using GWAS fine-mapping T1GRS and SHAP-based subclustersNature Genetics · 2026 · read 2026-05-15article★★★☆☆014Harnessing the Power of Biomarkers for Diffuse Intrinsic Pontine GliomasNews & Views on biomarker-informed profiling and targeted therapy selection in H3K27-altered DIPGNature Medicine · 2026 · read 2026-05-15article★★☆☆☆013Optimizing Colorectal Cancer Screening through Polygenic Risk Score-Based Risk Stratification: Evidence from a Population-Based Cohort and Screening TrialArticle on PRS-based colorectal cancer risk stratification and risk-adapted screening using CKB and TARGET-CGenome Medicine · 2026 · read 2026-05-15article★★★☆☆012Systemic Inflammatory Biomarkers as Risk Factors for Age-Related Ocular Diseases: A Large-Scale Prospective Cohort StudyProspective UK Biobank cohort study on systemic inflammation biomarkers and age-related ocular disease riskBritish Journal of Ophthalmology · 2026 · read 2026-05-15article★★★★☆011Semi-Supervised Disentangled Representation Learning for Single-Cell RNA Sequencing DataMethod article on semi-supervised disentangled representation learning for scRNA-seq dataBriefings in Bioinformatics · 2026 · read 2026-05-14article★★☆☆☆010Toward Trustworthy Artificial Intelligence in Multi-Omics: A Review of Reproducibility Stability and InterpretabilityReview on trustworthy AI in multi-omics focusing on reproducibility stability interpretability and the TRUST frameworkBriefings in Bioinformatics · 2026 · read 2026-05-14review★★★☆☆009Multimodal Clocks of Human AgingResource article on multimodal human aging clocks and coagulation factors as aging biomarkers and driversCell · 2026 · read 2026-05-14article★★★★☆008Spatial Transcriptomics Combined with Single-Cell RNA-sequencing Unravels the Complex Inflammatory Cell Network in Atopic DermatitisArticle on spatial inflammatory cell networks in atopic dermatitis lesions by spatial transcriptomics and scRNA-seqAllergy · 2023 · read 2026-05-14article★★★☆☆007Best Practices for Single-Cell Analysis across ModalitiesReview on best practices for single-cell analysis across modalitiesNature Reviews Genetics · 2023 · read 2026-05-08review★★★★☆006Single-Cell Transcriptome Analysis of Human Skin Identifies Novel Fibroblast Subpopulation and Enrichment of Immune Subsets in Atopic DermatitisArticle on local skin tissue inflammatory circuits in atopic dermatitis by scRNA-seqThe Journal of Allergy and Clinical Immunology · 2020 · read 2026-05-06article★★★☆☆005Mapping the Immune Cell Landscape of Severe Atopic Dermatitis by Single-Cell RNA-seqArticle on systemic immune cell remodeling in severe atopic dermatitis by PBMC scRNA-seqAllergy · 2024 · read 2026-05-06article★★★☆☆004Automated Methods for Cell Type Annotation on scRNA-seq DataReview on automated cell type annotation methods for scRNA-seq dataComputational and Structural Biotechnology Journal · 2021 · read 2026-05-05review★★★☆☆003Cell Death in CancerReview on regulated cell death programs in cancerCell · 2026 · read 2026-04-29review★★★★★002Endotypes of Atopic DermatitisReview on atopic dermatitis endotypes and precision medicineThe Journal of Allergy and Clinical Immunology · 2025 · read 2026-04-21review★★★★★001Single-cell biology: what does the future hold?Editorial on the future of single-cell biologyMolecular Systems Biology · 2023 · read 2026-04-13editorial★★★☆☆